Detalhe da pesquisa
1.
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Cell
; 185(13): 2213-2233.e25, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35750033
2.
A Tale of Two Genes: Microglial Apoe and Trem2.
Immunity
; 47(3): 398-400, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930654
3.
Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice.
Int J Mol Sci
; 25(5)2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38473822
4.
APOE and immunity: Research highlights.
Alzheimers Dement
; 19(6): 2677-2696, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975090
5.
APOE4 confers transcriptomic and functional alterations to primary mouse microglia.
Neurobiol Dis
; 164: 105615, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35031484
6.
Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome.
Ann Neurol
; 89(1): 54-65, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32996171
7.
Genome-wide association study and functional validation implicates JADE1 in tauopathy.
Acta Neuropathol
; 143(1): 33-53, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34719765
8.
Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response.
Neurobiol Dis
; 148: 105217, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33301878
9.
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
Mol Psychiatry
; 25(8): 1859-1875, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108311
10.
Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
Mol Psychiatry
; 25(8): 1901-1903, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31636380
11.
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J Biol Chem
; 293(32): 12634-12646, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29794134
12.
Functional annotation of genomic variants in studies of late-onset Alzheimer's disease.
Bioinformatics
; 34(16): 2724-2731, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29590295
13.
BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues.
Nat Commun
; 15(1): 2058, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38448474
14.
BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer's disease and other disorders of lipid-rich tissues.
bioRxiv
; 2023 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36824752
15.
The complex genetic architecture of Alzheimer's disease: novel insights and future directions.
EBioMedicine
; 90: 104511, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36907103
16.
A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
J Exp Med
; 220(11)2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37642942
17.
The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.
Hum Mol Genet
; 19(22): 4373-84, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20739295
18.
Microglial efferocytosis: Diving into the Alzheimer's disease gene pool.
Neuron
; 110(21): 3513-3533, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36327897
19.
Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk.
Mol Neurodegener
; 16(1): 27, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33882988
20.
The variant call format provides efficient and robust storage of GWAS summary statistics.
Genome Biol
; 22(1): 32, 2021 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33441155